Duricef (Cefadroxil)

Duricef Review

This medication is a cephalosporin-type antibiotic used to treat a wide variety of bacterial infections (e.g., skin, bone and genitourinary tract infections).

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Duricef Drug Class and Mechanism

Cephalexin belongs to a class of antibiotics called cephalosporins. They are similar to penicillin in action and side effects. They stop or slow the growth of bacterial cells by preventing bacteria from forming the cell wall that surrounds each cell. The cell wall protects bacteria from the external environment and keeps the contents of the cell together.

Duricef Uses

Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacteria "Streptococcus pyogenes", otherwise known as strep throat.Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil. The usual adult dose is 1 to 2 g daily as a single dose or in two divided doses. The following doses are used in children weighing less than 40 kg: 500 mg twice daily for those over 6 years of age, 250 mg twice daily for those aged 1 to 6 years, and 25 mg/kg daily in divided doses for infants under 1 year.

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Duricef Side Effects

The most common side effects of cephalexin are diarrhea, nausea, abdominal pain, vomiting, headaches, dizziness, skin rash, fever, abnormal liver tests and vaginitis. Individuals who are allergic to penicillin may also be allergic to cephalexin. Cephalexin, like almost all antibiotics, may cause mild or severe cases of pseudomembranous colitis, a mild to severe inflammation of the colon. Antibiotics, including cephalexin alter the normal flora of the colon and permit overgrowth of a bacterium called Clostridium difficile. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis.

Duricef Pregnancy

Reproduction studies have been performed in mice and rats at doses up to 11 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to cefadroxil monohydrate. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Duricef Overdose

A study of children under six years of age suggested that ingestion of less than 250 mg/kg of cephalosporins is not associated with significant outcomes. No action is required other than general support and observation. For amounts greater than 250 mg/kg, induce gastric emptying. In five anuric patients, it was demonstrated that an average of 63% of a 1 g oral dose is extracted from the body during a 6-8 hour hemodialysis session.

Duricef More Information

Patients should be counseled that antibacterial drugs including DURICEF should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When DURICEF is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance and will not be treatable by DURICEF or other antibacterial drugs in the future.